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Study to determine how imatinib exerts its anti-tumor effects, we demonstrated that insulin-like growth factor binding protein-3 (IGFBP3) expression is up-regulated after imatinib treatment in the imatinibresponsive GIST cell line GIST882 as well as KIT-expressing tumor samples [12]. IGFBP3, a member of the insulinlike growth factor binding protein family, is a multifunctional protein that directl

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