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Onstrate that IGFBP3 has dual, opposing cell line-dependent effects on GIST cell survival.IGFBP3 modulation alters GIST cell sensitivity to imatinib in a cell-dependent manner The above studies show a complex pattern of IGFBP3 function in regulating GIST cell survival. To determine whether IGFBP3 contributes to GIST cell response or resistance to imatinib, we modulated IGFBP3 protein levels in GIS

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